TY - JOUR T1 - Metabolic effects in patients with celiac disease, patients with nonceliac gluten sensitivity, and asymptomatic controls, after six months of a gluten-free diet JO - Revista de Gastroenterología de México T2 - AU - Remes-Troche,J.M. AU - Cobos-Quevedo,O. De J. AU - Rivera-Gutiérrez,X. AU - Hernández,G. AU - de la Cruz-Patiño,E. AU - Uscanga-Domínquez,L.F. SN - 2255534X M3 - 10.1016/j.rgmxen.2019.02.011 DO - 10.1016/j.rgmxen.2019.02.011 UR - http://revistagastroenterologiamexico.org/en-metabolic-effects-in-patients-with-articulo-S2255534X19300520 AB - Introduction and objectivesIt is essential for patients with celiac disease (CD) to be on a gluten-free diet (GFD) but said diet has also been reported to increase the risk for metabolic syndrome. There is no evidence on the metabolic effects of a GFD in patients with nonceliac gluten sensitivity (NCGS) or in asymptomatic subjects. Therefore, the aim of the present study was to evaluate the metabolic effects of a GFD over a 6-month period in patients with CD, patients with NCGS, and in asymptomatic controls (ACs). Materials and methodsA prospective study was conducted that evaluated metabolic syndrome and its components of obesity, high blood pressure, hepatic steatosis, and hyperglycemia at the baseline and at 6 months. ResultsA total of 66 subjects (22 CD, 22 NCGS, and 22 AC) were included in the study. At the baseline, 10% of the patients with CD presented with obesity, high blood pressure, hepatic steatosis, and metabolic syndrome. After 6 months, obesity and metabolic syndrome increased by 20% (p=0.125). In the patients with NCGS, obesity increased by 5% after the GFD and 20% of those patients presented with de novo hepatic steatosis. The prevalence of obesity decreased by 10% in the controls after the GFD (30 vs 20%, p=0.5) and none of the other components of metabolic syndrome were affected. ConclusionsThe metabolic benefits and risks of a GFD should be considered when prescribing said diet in the different populations that opt for that type of intervention. ER -